Molecular modeling of biomedically important proteins

Molecular models of proteins involved in human health. Top, CACNA1A, a protein that is expressed in the brain that is connected to neurodegenerative diseases (Nibbeling et al. 2017, Brain). Bottom, PADI3 protein, involved in CCCA, a skin disorder leading to hair growth problems (Malki et al. 2019 New England Journal of Medicine)

We collaborate with researchers from many fields of biology and medicine, in Israel and abroad, on deciphering molecular mechanisms by building homology based models of proteins of interesting systems. This is especially true of understanding how mutations in proteins lead to human syndromes and diseases. Our expertise in structural biology and biochemistry allow us to build models that can lead to experiments that can prove or disprove our suggestions as to the connection between mutations and disease.